Program Schedule

Keynote Speaker

Vilma Alejandra Umanzor
Profesor Department of Periodontics in Dentistry Faculty National Autonomous University of Honduras
Title: Use of cone beam computed tomography imaging as an alternative for the diagnosis and treatment planning of a mucogingival condition : Altered Passive Eruption

Biography: Doctor in Dental Surgery Catholic University of Honduras Specialist in Periodontics and Implantology (National Autonomous University of Mexico) Instructor Periodontics Department in the Dentistry Faculty National Autonomous University of Honduras Member of The Mexican Association for Periodontology Speaker For Colgate-Palmolive Honduras Ceo Dsd Radiodiagnostico National And International Speaker

Abstract: Passive Altered Eruption (PAE) is a condition described as mucogingival deformity which rises an important esthetic concern for the patient. This clinical scenario often encourages patients to seek treatment to improve esthetics and selfesteem. For some authors, describe PAE as a failure of the passive eruption phase to conclude and the gingival margin mantains a more coronal position on the enamel and much more coronal to the cemento-enamel junticion. The diagnosis for PAE has been traditionally based on conventional methods such as sounding, bone sounding and through radiographic evaluation to determine the correct surgical approach requiring an increased number of visits, procedures and costs for the patient. The introduction of cone bean computed tomography has been used for dentistry for decades now and has been used for different disciplines in dentistry including periodontics. CBCT imaging is considered as a solid tool established for treatment planning with augmented accuracy. The use of cone beam computed tomography for passive altered eruption cases is proposed to simplify and provide an objetive diagnosis and therefore obtaining and accurate individualized treatment plan that also brings successful clinical results. Materials and methods: A patient diagnose with PAE, in the six upper anterior teeth, the data was recorded to obtain measurements of ; size of the clinical crown, position of the cementum-enamel junction (CEJ), position of the crestal bone and quantity of gingival tissue with the sounding and bone sounding, compared with the use of the CBCT imaging for acquiring the latter mentioned measurements. All the data was recorded and analyzed to perform the crown lengthening surgery with our without osteotomy. The results obtained with the measurements of the differences between the clinical traditional technique and the CBCT gave a minimal statistical difference with no clinical significance during the procedure. With these results it can be concluded that the difference between the traditional clinical sounding and bone sounding technique and the CBCT measurements is minimal, which can be traduced clinically as a feasible and objective option for the diagnosis and treatment planning for PAE.


Orthodontics &Dentofacial Orthopedics

Session Introduction

Anjana Venugopal
Orthodontics
Title: The saga of ATM

Biography: Dr.Anjana Venugopal, has over 10 years of Dental experience and 7 years of experience as a Specialist in the field of Orthodontics. Trained formally in Toronto, she likes to take up clinical challenges that pushes her to expand the realm of conventional Orthodontics. She believes in catering to the patient's idea of a happy smile, achieved with stable methods of Orthodontic tooth movement. Dr.Anjana lives with her family in Dubai, United Arab Emirates.

Abstract: Accelerated tooth movement is fairly new and relatively untried in the field of Orthodontics. However its mention lights up the face of every clinician who as an Orthodontist would benefit ,in terms of treatment time. Is that a plus for us or for our patients? This presentation is to throw light on various modes of achieving accelerated tooth movement in Orthodontics and a case study using one such minimally invasive method- Piezoincision. Adult treatment although time consuming has been proven to be effective in the long term. However reduction of active treatment time, largely improves patient acceptability and compliance.


Hazem Hasan
Department of Orthodontics Faculty of Dentistry,Tishreen University, Lattakia, Syria
Title: A comparative study between the effect of Platelet Rich Plasma (PRP) AND Corticotomy on accelerating Orthodontic Tooth Movement In Adults

Biography: 2017 to now : Vice President of Tishreen University for Scientific Affairs and Scientific Research. 2013-2017 : Dean of the Faculty of dentistry, Tishreen University Supervision of more than fifty-five Master's degree Participating in university recruitment committees and promotion committees to the rank of professor and assistant professor in the universities of the Syrian Arab Republic

Abstract: The aim of this study was to (1) evaluate the effect of Platelet Rich Plasma (PRP) in accelerating tooth movement And to (2) identify the effect of the PRP on orthodontic tooth movement compared with Corticotomy: Materials and Methods: The sample in this clinical trial study consisted of 30 adult pataints with therapeutic need for extraction of maxillary first premolars and maximum canine retraction. By use of split mouth design, at the time of premolars extraction, corticotomy was performed around the maxillary first premolar, randomly on one side of maxilla, and The injection of PRP was applied on the other side . Our stydy still on progress, and our first results show: The prp technique doubled the rate of orthodontic tooth movement.


Sleiman Ahmad
Department of Orthodontics Faculty of Dentistry,Tishreen University, Lattakia, Syria
Title: A comparative study between the effect of Platelet Rich Plasma (PRP) AND Corticotomy on accelerating Orthodontic Tooth Movement In Adults

Biography: phd at Orthodontics and Dentofacial Orthopedic Department, Dental School at Tishreen University. sleimanortho@gmail.com 2011 to 2016 master in orthodontics Honours and awards : -Bassel Award for Academic excellence ( third rank) in the 4th year faculty of dentistry - Graduated with a high level ( second top ). The top grade in applying for high studies (first rank).

Abstract: The aim of this study was to (1) evaluate the effect of Platelet Rich Plasma (PRP) in accelerating tooth movement And to (2) identify the effect of the PRP on orthodontic tooth movement compared with Corticotomy: Materials and Methods: The sample in this clinical trial study consisted of 30 adult pataints with therapeutic need for extraction of maxillary first premolars and maximum canine retraction. By use of split mouth design, at the time of premolars extraction, corticotomy was performed around the maxillary first premolar, randomly on one side of maxilla, and The injection of PRP was applied on the other side . Our stydy still on progress, and our first results show: The prp technique doubled the rate of orthodontic tooth movement


farida AMMOUCHE

Title: Dental crowding and frequency of permanent tooth extractions in orthodontic treatment

Biography: Dentist Specialist in Orthodontics practicing at Mustapha University Hospital in Algiers and Associate Professor at the Faculty of Medicine of Algiers: Department of Dental Medicine.

Abstract: A study conducted in the ODF service of the CHUM showed that dental crowding is the most frequent reason for dental consultation among our patients with a tendency to extract the first premolars as a therapeutic solution. In most cases a dental crowding is linked to the premature extraction of primary teeth or to a maxillo-mandibular hypodevelopment due to functional disorders. Can we avoid extracting? Early management is an unavoidable alternative in some cases to intercept dental crowding knowing that late treatment often leads the practitioner to extract permanent teeth to create space on the arches.


ABU-HUSSEIN MUHAMAD
Limited to Pediatric Dentistry DDS,MSc,MScD,Cert.Ped. Athens-Greece
Title: Canine Impactions- surgical and orthodontic considerations Abu-HusseinMuhamad

Biography: -DDS 1986 ,DPD(Drodont)Dentistry for Children1988 -International Short-Term Programme in Orthodontics1994,6WEEKS Aarhus,Denmark -Postgraduate taught course (two-years) in Oral Biology/Pathology, Dental Faculty, University of Athens 1998 -Master of Biostatistics,School Mathematics/Medicine,Athens2001 Postgraduate Bioesthetic Dentistry. OBI,International Faculty -Diploma. Roth/Williams Center for Functional Occlusion -Short course: Molecular Epidemiology of Chronic Disease and the Exposome,30 Sep, 2001 to 04 Oct, 2001, Utrecht University -2003- 2005 : New York University College of Dentistry Implants "Aesthetics and Occlusion Oral Rehabilitation in Current Concepts in American Dentistry in continuing Dental Education Program"Athens,Greece -Certificate of Attendance the course on: “Orthodontic treatment with the magic lingual system – theoretical basis and clinical practice”,Prof.Ol.Sorel,Ispringen, Dentaurum,Germany,June 30th-10July 1st,2007 -OVER 3000 HOURS WITHIN THE LAST 10 YEARS, RELATED TO ENDODONTICS,PROSTHODONTIC,PERIODONTOLOGY, DENTAL IMPLANT, IMPLANT BIOMECHANICS, OCCLUSION AND COSMETIC DENTISTRY. -250publications as author or co-author in peer-reviewed journals/bookchapters -180 lectures and CE courses(Cleft lip/palate,Pediatric Dentistry) in many countries .

Abstract: The permanent canines are the foundation of an esthetic smile and functional occlusion. Factors that interfere with its development and eruption had serious consequences on esthetics, function and stability of stomatognathic system.[1,,2,3,4,5] Many authors speculated about the cause of impacted mandibular canines.[5,6] These causes include inadequate space, supernumerary teeth, and premature loss of the deciduous canine, excessive crown length, hereditary factors, and functional disturbances of the endocrine glands, tumors, cysts and trauma. Impacted mandibular canines are also more likely to be located on the labial aspect of the dental arch than are maxillary canines Shafer et al. suggested the following sequela of canine impaction: labial or lingual malpositioning of impacted tooth, migration of the neighboring teeth and loss of dental arch length, internal resorption, dentigerous cyst formation, infection particularly with the partially erupted tooth. Partly erupted or impacted cuspids may increase the risk of infection and cystic follicular lesions and compromise the lifespan of neighboring lateral incisors due to root resorption.[7,8,9,10,11,12,13] The different methods of diagnosis that may allow for early detection and prevention should include a family history, visual and tactile clinical examinations by the age of 9-10 years and a thorough radiographic assessment.[-1, 13, 14] Because there is a high probability that palatally impacted maxillary canines may occur with other dental anomalies, the clinician should be alert to this possibility. [15,16]When the condition is identified early, extraction of the deciduous canines may, in specific cases, allow the impacted canines to correct their paths of eruption and erupt into the mouth in relatively good alignment. Clinical signs that may indicate ectopic or impacted cuspids include lack of a canine bulge in the buccal sulcus by the age of 10 years, over retained primary cuspids, delayed eruption of their permanent successor and asymmetry in the exfoliation and eruption of the right and left canines.(17,18,19] In conclusion, the management of impacted canines has a multidisciplinary approach as it plays a vital role in esthetics and function. Surgical exposure and orthodontic correction is the most preferable treatment unless contraindicated. Extraction of the impacted canine should be the last resort, as every impacted canine should be treated in a hostile way to prevent its complications.[2,4,5,7,9,11,12,17,18,19] This presentation reviews its diagnosis and treatment plan in an orthodontic and surgical aspect.


Mahmoud Mohammad kodeha
Dentist, Tanta Gharbeya, Egypt.
Title: Sub-gingival Simvastatin / Chitosan gel in The Treatment of Chronic Periodontitis in Smokers.

Biography:

Abstract: Aim of the work: The present study was designed to evaluate clinically & radiographically the effect of sub-gingival delivered simvastatin with / without chitosan gel in the treatment of chronic periodontitis among smokers. Methods: Twenty smoker patients with moderate to severe chronic periodontitis (40 sites) selected and divided into 4 treatment groups (split mouth study)10 sites in each group as : group A , sites received scaling & root planing (SRP) + SMV gel. group B , sites received SRP + chitosan gel . group C , 10sites received SRP +(SMV+ chitosan) gel and group D, sites received SRP alone and served as a control. The clinical parameters were recorded , at baseline (before SRP) , after 1 , 3 and 6 months they included: plaque index (PI), bleeding on probing (BOP), gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL). At baseline and after 6 months, radiologic assessment of intrabony defect (IBD) fill was done using computer-aided software.


Prof Anmol S Kalha osre
Prof Emeritus ,Distinguished Professor and Advisor CIDS Assoc Director & Advisor , Max Health Care Chief Architect and Cofounder Medeva Knowledge Systems
Title: Optimism in Orthodontics: Energy, Knowledge, Entropy

Biography: A 40 year diverse and chequered global experience in Orthodontics ,oral health sciences , health care administration , national health care policy , international research and consultancy. Has lectured in over 46 countries around the globe and has published extensively, serves on the editorial board of key journals, EBD UK , EAPD and several others . Has a key clinical practice in Delhi with a focus on adults , aesthetics, sleep medicine. Was recently invited to speak at the prestigious International Orthodontic Symposium in Prague, Delivered the Indian Orthodontic Society Oration 2017 , Selected for the Outstanding Professor award by the IOS 2018, received a lifetime achievement award in military dentistry form the FDI-SFDS. Has a royal decoration from Oman for distinguished services .An avid reader , writer and keen golfer .Currently he is a distinguished professor and advisor to a prestigious institution in southern India , also is the cofounder of Medeva Knowledge Systems , AI , ML Health analytics .

Abstract: Optimism in orthodontics seems to be on the wane with challenges as diverse as technology, appliances,adults, treatment delivery systems, low fee competition and spiraling costs. Consistency of care is compromised on a platform of differential training focused on appliance systems. Simplicity is a quest. Equilibrium, soft tissue volume and occlusal challenges in deteriorating occlusions are the emerging issues. A need to understand age, facial aesthetics, accurate positioning of the dentition in support of occlusal goals defines the challenges today. As digital technologies redefine the clinical environment, transformation from a reactive to predictive model is self-evident. Precise aesthetic appliances, efficient treatment lines and care protocols, customized solutions all bring optimism. Its Knowledge that will simplify orthodontics and reduce entropy. This lecture will address the challenges of diagnosis, treatment planning, appliance selection, prescription and clinical manipulation of appliances in the process of simplifying orthodontics. Optimism is a natural consequence. It’s about redefining the clinical and diagnostic paradigm in orthodontics .


Ms Naira Figueiredo Deana
Master in Dentistry, Universidad de La Frontera Research Assistant in CIEESPO, Faculty of Dentistry, Universidad de La Frontera
Title: Photobiomodulation in orthodontic pain management: a double blinded, split-mouth, randomised, controlled clinical trial

Biography:

Abstract: The beneficial effects of orthodontic treatment on dental aesthetics can be observed from the first months, however some unwanted effects have been reported by patients during treatment, such as pain after installation of the orthodontic apparatus.The aim of this study was to assess the effectiveness of photobiomodulation(PTBM) in reducing orthodontic pain after the installation of light arches. Design, Setting, and Participants.Double blinded, split-mouth, randomised, clinical trial in patients with installation of first orthodontic arch between March and December 2018. There were 32 participants, of both sexes, aged 13 years or more. Intervention. Treatment with PTBM, diode laser AlGaAs 808 nm, doses of 120 J/cm2 (EG1) and 240 J/cm2 (EG2). The follow-up period was 1 month. Main outcome measure. Spontaneous pain and pain in occlusion were assessed by the Visual Analogue Scale at 5 minutes, 24, 48 and 72 hours after placement of first orthodontic archwires.


Dr William Graham Gardner
Virginia Commonwealth University Department of Orthodontics
Title: Invisalign Jedi Master

Biography: After graduating from the NYU orthodontics program in 1998, Dr. Gardner has been practicing in his private practice in Richmond, Virginia. He immediately started teaching part-time at Virginia Commonwealth University Department of Orthodontics. He has treated over 3000 Invisalign cases and is part of Invisalign Faculty. Interdisciplinary orthodontics is his hobby and his passion!

Abstract: Abstract:Interdisciplinary treatment has had some exciting innovations in the orthodontic world. Dr. Gardner will review topics such as facially generated treatment planning, printing out Invisalign predictions to create wax-up models, bone-building for implant site development, orthodontic anchorage to achieve better results, and placing implants early in a predictable manner to use for orthodontic anchorage. This lecture will show you how incorporating orthodontics into your treatment plan properly can expand your ability to provide excellent results in your complex cases.


Endodontics

Session Introduction

Humaira anjum baig
BDS, MDS, Certificate course from Lille University(France)
Title: The Tissue Reaction To certain Retrograde Filling materials Employed In Endodontic Practice – An Experimental Study

Biography: Academic and Professional Qualifications: 1. Masters in Dental Surgery (MDS) – Endodontics & Conservative Dentistry – Year 1995. Institute - University of Mumbai - Govt. Dental College & Hospital, Mumbai. 2. Bachelor in Dental Surgery (BDS) – Year 1989. Institute - Govt. Dental College & Hospital, Mumbai. Marathwada University. 3. Certificate Course from Lille University, Medical School, France. – Year 2005 Course- Fundamental Basic & Clinical science for Routine Implant Dentistry. Clinical Experience: Total 25 yrs of experience in the field of Endodontics & Conservative Dentistry. 1. 1st January 2014 to till date. Advanced Dental Care Center. Mumbai, India. Position- Medical Director & Sr. Consultant, Endodontics & Conservative Dentistry. 2. May 2010 to November 2013. Medical Center - King Fahad University of Petroleum & Mineral Sciences. (KFUPM) Dhahran, Saudi Arabia. Position- Specialist Endodontist. 3. August 2003 to Feb 2010 Al Rajhi International Clinics, Al Khobar, KSA Position- Specialist Dentist. 4. March 2000- August 2003. Kashghari Dental Center. Al Khobar, KSA Position- Specialist Endodontist. 5. March 1996- August 2000. Kashghari Dental Center. Al Khobar, KSA Position- Specialist Dental Surgeon. 6. March 1990- August 1992. Govt. Dental College. Aurangabad, India. Position- Asst. Lecturer & Dental Specialist 7. March 1989- August 1990. Govt. Dental College. Aurangabad, India. Position- Clinical Associate. Teaching Experience: 1. Served as Asst. Lecturer. (1990-1992) Dept. of Endodontics, Govt. Dental College, Aurangabad. India. (Maharashtra University) 2. Served as Asst Lecturer for undergraduate students during MDS. (1992-1995) University of Mumbai - Govt. Dental College & Hospital, Mumbai * Under the university curriculum- conducting lectures, presentations, seminars for BDS students. * Conducting examination, invigilation, evaluation of exams in accordance with the University guidelines. * Conducting & supervising clinical sessions for the Dentist interns & students and providing them the required guidance and assistance. * Training of Dental Assistants & Nursing staff.

Abstract: A sample of 64 pellets of polycarboxylate cement & chemically activated composite resin- retrograde filling materials, was used to study the tissue response in albino rats of Wister strain. These materials were implanted in the subcutaneous tissue of 16 adult albino rats, equally distributed into 4 groups for various observation periods i.e.3,10,20 and 30days. Under G.A. using ether after preparation of the part,4 incisions were made and 2 pellets of each material were implanted below the skin and the wounds were sutured & post operatively the animals were observed. Healing was normal and uneventful. The animals were then sacrificed & the tissue spp.containing the pellets were obtained, fixed in formalin, dehydrated in graded ethyl alcohol, cleared in xylene,embedded in paraffin wax & bocks were prepared. Six micrometer thick sections were made & stained with haematoxylin and eosin. The stained sections were subjected to histological examination and the results were tabulated.


Arthur Goren
Adjunct Clinical Professor Department of Cariology & Comprehensive Care New York University College of Dentistry New York
Title: Dosimetry of 4 CBCT Machines For Endodontic Procedures

Biography:

Abstract: Background: No studies have been done to evaluate radiation exposure to a 30 year old female CIRS phantom using OSL dot dosimetry utilizing three dimensional imaging for endodontic purposes. Methods: An anthropomorphic phantom corresponding to a 30 year old female was used for all exposures. CBCT scans were taken on a Sirona Orthophos SL machine , a Morita 3D Accuitomo machine, a Kodak 9000 machine , and an Instrumentarium 300 machine. The preset endodontic settings for maxillary anterior, premolar and molar were used for the all the CBCTs. The field of view selected was to image the anterior maxilla and the maxillary first molar. Dosimetry was performed using optically stimulated luminescent (OSL) dosimeters. The effective radiation dose was calculated for the organs of the head and neck. Organ fractions irradiated were determined from ICRP-89. Overall effective doses were calculated in micro-Sieverts for the results and were based on the ICRP-103 tissue weighting factors. Results: The effective doses measured with the Kodak CBCT were significantly less when compared to those taken with the other CBCTs. The highest organ dose exposures were in the salivary glands, oral mucosa, and extrathoracic airway. The differences between the CBCTs in the dosimetry was due to differences in the field of view and tube current settings. Conclusion: This was the first study to evaluate radiation exposure to a female CIRS phantom using OSL dot dosimetry using three dimensional imaging for endodontic purposes. Restricting the field of view and selective tube current allows CBCT imaging to be used for endodontics following the ALARA principle.


Sevan Harzivartyan
5th grade student in Faculty of Dentistry, Marmara University, Istanbul, Turkey
Title: Evaluation of Different Irrigation Solutions on Removing Calcium Hydroxide

Biography: My name is Sevan Harzivartyan. I was born on 12th of May in 1994, in İstanbul. I finished elementary school in Pangaltı Armenian School. After completing my education there, I went to Üsküdar American Academy and graduated with honors. I was accepted to Marmara University, Faculty of Dentistry in 2013. I am a senior student and have been continuing my education with both practical and theoretical courses. For the last 18 months I have been working on this research with Prof. Dr. Hale Cimilli, Prof. Dr. Nevin Kartal and Prof. Dr. Afife Binnaz Hazar Yoruç.

Abstract: To evaluate the efficacy of Dual Rinse HEDP with different irrigation activation systems on removing calcium hydroxide [Ca(OH)2] Fifty maxillary central incisor teeth were shaped using ProTaper Next. The teeth were split in half longitudinally and a standard groove on the apical third was prepared. The root halves were reassembled and the root canals were filled with Ca(OH)2. The teeth were stored for 10 days in 37oC, 100% humidity and divided into 2 groups according to the solution used to remove the intracanal medicament. These 2 groups are divided into 2 subgroups according to the irrigation activation technique. In group 1 (n=10) Ca(OH)2 was removed using conventional irrigation with 5 ml of 1% sodium hypochlorite (NaOCl) whereas in group 2 (n=10) sonic irrigation (EndoActivator) with 5 ml of 1% NaOCl was used. Group 3 (n=15) and group 4 (n=15) received 5 ml of 1% NaOCl - Dual Rinse HEDP® mixture with conventional irrigation and sonic irrigation respectively. The amount of remaining Ca(OH)2 in the artificial grooves were evaluated under a light microscope at 50x magnification using a 4 degree scoring system. Data were analysed using Mann-Whitney U tests. There was significant difference between group 1 and group 2 (p=0,013). Group 2 had lower scores than group 1. No significant difference was found between groups 3 & 4, groups 1 & 3 (p>0.05). None of the irrigation procedures managed to completely remove the Ca(OH)2 from artificial grooves. Dual Rinse HEDP® was more efficient than NaOCl when used with conventional irrigation, on removing Ca(OH)2 from simulated canal irregularities. Conversely when sonic activation was used, both solutions resulted the same efficacy on removing the intracanal dressing.


Arezoo Pirhaji
1Department of Endodontics, Oral and Dental Diseases Research Center
Title: Comparison of Coronal Leakage in Tooth Preparation with Two Single File Systems and Three Obturation Techniques

Biography:

Abstract: Aims and Objectives: Root canal preparation and obturation are of great importance in endodontics. Its purpose is to eliminate pulpal and peri radicular disease. The aim of this study was to compare coronal bacterial micro leakage in prepared root canals using Neoniti A1 and Reciproc files that obturated with lateral compaction, single cone gutta percha, and hybrid (tapered cone/lateral compaction) methods. Materials and Methods: In this ex vivo study, a total of 110 single rooted mandibular first premolars were choose and randomly divided into two study groups A and B (each 45) that one group was prepared with Reciproc and another with Neoniti A1 and negative and positive control groups (each 10). Each group divided into three subgroups of 15 each and obturated using a single cone, lateral compaction, and hybrid (tapered cone/lateral compaction) techniques. For evaluation of coronal leakage, “two chamber setup” was used. The solution of enterococcus faecalis culture was injected in the upper chamber and incubated. If the bacteria pass through the canal and obturation materials, the lower chamber becomes turbid. TSB medium in the lower chamber (apex) were investigated every day in terms of occurrence of turbidity, and the duration of occurrence of leakage was recorded. The data were analyzed using Chi square test. Results: Data analysis showed that in each group the difference in percentages between subgroups was statistically significant (P= 0.003). So that the highest and the lowest amount of leakage in both groups were related to lateral compaction and hybrid techniques, respectively. Conclusion: Under the conditions of this study, independent of the instrument used for canal preparation, hybrid method and then single cone technique, however, were more effective in the prevention of coronal leakage than lateral condensation technique.


Eshaghali Saberi
Oral and Dental Diseases Research Center, Department of Endodontics, Dental School, Zahedan University of Medical Sciences, Zahedan, Iran
Title: odonto/osteogenic differentiation and cytokine production by human stem cells of the apical papilla induced by biomaterials: A comparative study

Biography:

Abstract: Clinical applications of bioactive materials is increasing in biomedical tissue engineering. This study sought to assess the effect of calcium enriched mixture (CEM) cement, Biodentine, mineral trioxide aggregate (MTA), octacalcium phosphate (OCP) and Atlantik on proliferation, odontogenic/osteogenic differentiation and pro-inflammatory cytokine production by human stem cells of the apical papilla (SCAPs). Methods: The SCAPs were cultured and exposed to CEM cement, Biodentine, MTA, OCP, Atlantik and no biomaterial (control group). Proliferation of SCAPs treated with different biomaterials was evaluated using trypan blue exclusion test and flow cytometry. Differentiation of cells was evaluated using alkaline phosphatase (ALP) activity, alizarin red staining and reverse transcription polymerase chain reaction (RT-PCR). The expression of genes of pro-inflammatory cytokines was also evaluated using RT-PCR. Results: The SCAPs treated with 20 mg/mL CEM cement, 2 mg/mL Biodentine, 200 µg/mL OCP/MTA and 20 µg/mL Atlantik showed significantly higher proliferation, increased ALP activity, higher number of calcified nodules and up-regulation of genes related to odontogenic/osteogenic markers [including ALP, Runt-related transcription factor 2 (RUNX2), osterix (OSX), osteocalcin (OCN), bone sialoprotein (BSP) and dentin sialophosphoprotein (DSPP)] compared to the control group. The expression of pro-inflammatory cytokines namely interleukin (IL)-1α, IL-1β, IL-6 and tumor necrosis factor (TNF)-α significantly increased in all groups compared to the control group. The highest expression on day 7 belonged to IL-1α and IL-1β in SCAPs treated with MTA, IL-6 in SCAPs treated with CEM cement, and TNF-α in SCAPs treated with Atlantik and OCP. Conclusion: CEM cement, Biodentine, MTA, OCP and Atlantik can induce odontogenic/osteogenic differentiation in SCAPs. MTA had a greater potential for induction of differentiation of SCAPs to odontoblast-like cells while OCP had higher potential to induce differentiation of SCAPs to osteoblast-like cells .


Doaa Mohamed Mohamed Sadony
Researcher at National reserch center,Giza,Eygypt
Title: Evaluation Antibacterial Effect of Diode laser in combination with or without Metallic Nanoparticles

Biography: Doaa sadony completed Bachelor of Oral and dental Medicine - Faculty of Oral and Dental Medicine,Cairo univeristy. Master degree from endodontic departme at Al-Azhar university, PhD from National Institute of Laser Enhanced Sciences (NILES) Cairo University. Now Resercher in National resercher center,Giza,Eygypt. Published papers in reputed journals and has been serving as an editorial board member of repute.

Abstract: Streptococcus mutans is the main etiological agent for dental caries. Recently, laser diode and metallic nanoparticles has been introduced as a new method in bacterial decontamination.Objective: Present study was conducted with the aim of evaluating antimicrobial efficacy of silver (AgNPs) and gold nanoparticles (AuNPs) with and without diode laser (970nm, 1.5 watt,C.W mode) irradiation against experimentally inoculated Streptococcus Mutans bacteria in infected root dentin as a container.Material and Methods:30 extracted single rooted human teeth were prepared and inoculated with Streptococcus Mutans for 24 hrs. The teeth were then randomly divided into 5 experimental groups. Group (I): AgNPs group (n=6): irrigation for 3minutes with 50 μl of 100 ppm, Group( II): AuNPs group(n=6): irrigation with 50 μl of 100 ppm, Group(III)( n=6): the AgNPs & diode lasers group: irrigation with 50 μl of 100 ppm + irradiation with 1.5W laser for 60 seconds, Group( IIII)(n=6): the AuNPs & diode lasers group: irrigation with 50 μl of 100 ppm + irradiation with 1.5W laser for 60 seconds. One control group(VI)(n=6) contain only the bacteria strain. The specimens were collected from the canal and colony forming units (CFU’s) were observed.Results:Significant difference was found among all the groups in comparison to the control group (p<0.05). The greatest reduction in CFU’s was observed with combination of AgNPs & diode lasers group. Application of diode laser in combination with silver nanoparticles had significant effects in the reduction of bacteria in comparison to other experimental groups. No significant differences were found among Au + diode laser group and control group, although significant difference existed among rest of the groups. The treatment in group (III) has the highest antibacterial effect by 90% followed by group (I) 80%, group (IIII) by 65 %, and the lower effect was group (II) 40% at the same time. Conclusions:AgNPs in combination with diode laser irradiation has the potential to be used as disinfectant in dentistry.Key words: Antibacterial efficacy, gold, silver, nanoparticles, diode lasers.


Dr. Carlos Manuel de Oliveira Nascimento
Specialist in Endodontics Master in Microbiology Residence in Endo Inn - Endodontic Training Center, Oslo, Noruega
Title: Endodontic treatment combined with apical micro-surgery: case report

Biography:

Abstract: Periapical micro-surgery is carried out with modern clinical microscopy equipment, allowing treatment to be applied with maximum precision and a high success rate. In the present study we report a clinical case of a male patient aged 15 years, with indication by his orthodontist for endodontic treatment due to the presence of an image suggestive of apical lesion in tooth 12 in a panoramic X-ray. The patient presented no kind of thermal sensitivity to horizontal and vertical percussion, and no signs of oedema or fistula were observed. Periapical X-ray and cone-beam computerised tomography were carried out, finding a periapical lesion of endodontic origin suggestive of granuloma. At first, non-surgical endodontic treatment was carried out, however the orthodontist indicated the need to start orthodontic treatment as soon as possible. It was therefore suggested that the endodontic treatment should be complemented by apical micro-surgery. In the first intervention the channel was prepared and disinfected by the classic method, with calcium hydroxide applied as intra-channel medication until the next session. In the second intervention, apical micro-surgery was carried out with retrograde instrumentation and obturation, and obturation with bioceramic cement. In the last intervention, the cervical 2/3 of the channel were filled with glass ionomer. The patient presented good evolution after the surgical procedure. After 6 months, a new periapical X-ray was taken. Good bone repair and integrity of the hard lamina were observed, allowing us to state that the case was successfully concluded.


Dental and Oral Health

Session Introduction

Ousman Touray

Title: Parental Perception of a Dental Home for Children with Special Needs

Biography:

Abstract: Objective The purpose of the study was to assess parental perceptions and acceptability of a dental home for their children with special needs, a novice concept in the State of Qatar. Methods A cross-sectional prospective study was conducted at Hamad Medical Corporation (HMC), in Qatar. Results A total of 102 questionnaires were completed (response rate = 98 %). Approximately 50% of participating parents were between 30 and 39 years of age, and 80% of them were females. Almost 50% of children included had global developmental delay, 28 % musculoskeletal disability, 9.8 % respiratory compromise on non-invasive ventilation, 7 % learning disability and 6 % had visual and hearing disabilities. Almost 70% of the participant children have other co-morbidities. When assessing parental knowledge and awareness of dental health, approximately 80 %participants parents believed that oral health affects total body wellbeing. Not surprisingly, only 4 % of parents stated that their children have excellent oral health. Approximately, 80 % of parents believed that the child’s primary care provider should start the dental home process. Interestingly, 64% of children have not had a routine dentist visit in the last 12 months preceding the interview. The reasons of not having such visits included the perception of waiting long time for an appointment (16%), difficulty in child mobility ( 12%), the thought that deciduous teeth don’t need care (5 %), the perception that dental care is expensive (3%), combination of above factors ( 38%) , and other factors ( children difficulty to handle during dental procedure, insurance issues, clinics far away, etc..). Approximately one in two of parents mentioned multiple problems (pain, cavities, halitosis, broken teeth, and teeth discoloration) in their children’s oral health, while only approximately 10 % reported solely caries. When asked of what factors will encourage participants to initiate a dental home for their children, 32 % of parents answered quick appointments, dentists specialized in pediatrics (31%), child friendly atmosphere (11%) , low cost (11%), close to home (10%), others (3.5%), and all of the above (37 %). Conclusion Parental perception is considered an important target for public health interventions. Our study has delineated the perceived obstacles to acquire a dental home faced by parents of children with special needs. The State of Qatar, a rapidly developing country, possesses vast resources including medical and dental field that can be utilized to create dental homes for children with special needs. Our next step will be to educate primary care physicians to guide parents of children with special needs to acquire a dental home


Helio Gomes da Silva
DDS, MSD, PHD - PhD in Dentistry (PHD dentristry
Title: The Importance of Functional Lingual Space for Health and Quality of Life

Biography: Dr. Helio Gomes da Silva, DDS, MSD, PHD - PhD in Dentistry (PHD dentristry), author of 03 books and several scientific articles correlating the deformations in the form and volume of the functional lingual space with several physical, chemical and emotional human being; developed the HGS-II, III and RA (intra-oral appliance for the treatment of Snoring and Nocturnal Apnea):; a researcher since 1990 on the situation of the functional occlusal plane in the malocclusions, focusing on orthodontic biomechanics and symptoms of temporomandibular dysfunction related to occlusal disharmonies, with repercussion in the spine at CTA- Research Center of the Brazilian Air Force in São José dos Campos, Brazil; (University of Taubaté-São Paulo), where he concluded a research (Thesis of Doctorate - 2014) on the daily performance and psychosocial conditions of young adults submitted to orthodontic treatment, currently coordinating professor of the postgraduate program in dentistry in orthodontics by the IMED Faculty (RS-Brazil) and IPENO Faculty (SC-Brazil).

Abstract: The importance of the functional lingual space for the health and quality of life of the human being was highlighted, initially by Willem Balters (German Doctor in 1962), when he concluded that the Glossiptose (diminution of space for the tongue), could affect the health physical, chemical and emotional. Since then, transverses, vertical and longitudinal dimensions deformations of the maxilla and mandible have been highlighted in various scientific articles, periodicals, books, etc. in Europe, South America, North America and especially in Brazil, as well as other countries. Several authors have also related the pathological alterations of the lingual space with several diseases, such as Respiratory Disorders, Dyspnea, Nocturnal Apnea, Rhinitis, Bronchitis, Bronchial Asthma, Gastritis, Esophagitis, Cardiac Diseases, CVA, Anxiety Depression, among others. Therefore, this work aims to present a deeper discussion about the pathophysiology of these functional alterations involving the lingual space, clinical cases seminars, as well as to propose some simple and effective intrabuccal resources for the coadjuvant treatment of obstructive sleep apnea syndrome (OSA) ), among other pathological conditions.


Dragana Dakovic
Department of Dentistry Medical Faculty of the Military Medical Academy University of Defence Crnotravska 17 Belgrade, Serbia
Title: Long-term efficacy of combined topical dexasone/tacrolimus on oral lesions of chronic Graft versus Host DiseaseLong-term efficacy of combined topical dexasone/tacrolimus on oral lesions of chronic Graft versus Host Disease

Biography:

Abstract: Oral involvement of chronic graft-versus-host disease (cGVHD) is the most distressing complication of haematopoietic stem cell transplantation. Management of oral cGVHD with palliative rinses, topical corticosteroids, calcineurin inhibitors and other therapies may require combined therapy. The aim of this study was to research the efficacy and safety of long-term treatment with combined topical agents (dexasone, tacrolimus, nystatin and anaesthetic solution) in the management of patients with symptomatic oral cGVHD. In this prospective cohort study, we evaluated pre-to-post treatment changes in 8 patients, during of 6 months. According to current National Institutes of Health consensus criteria, the clinical outcomes were assessed by the clinical oral cGVHD scoring system, oral cGVHD examination scores and treatment responses. Patients’ symptoms were registered using a visual analog scale (VAS) in dryness and pain score. Preliminary results showed that there was a significant decrease in the median oral cGVHD examination of the total score in pre-to-post group (p=0.01). The median pre-treatment was 6.0 (range 3.0 – 10.25), and median post treatment was 2.0 (range 1.0 – 2.0) for total score. There was a significant decrease from baseline in the median oral dryness score (p=0.01) and oral pain score (p=0.04). In conclusion, considering the chronic course of GVHD, a long-term maintenance treatment with combined topical rinse could be useful and safe to treat locally oral mucosa inflammation in chronic GVHD.


Muhammad Tayab
Sr-Clinical Lecturer of Orthodontics. Orthodontics department Bacha khan Dental College Mardan.
Title: CORRELATION BETWEEN MODIFIED MIDDLE PHALANX OF MIDDLE FINGER (MP-3) AND MANDIBULAR SECOND MOLAR MINERALIZATION STAGES

Biography: Muhammad Tayab Khalily trained as a dentist at Khyber Medical College now Khyber college of Dentistry and qualified in 1985. He worked for Twelve years as a in charge dental surgeon in Primary, Secondary ,and Tertiary hospitals of public health sector Khyber Pukhtoon khwa Pakistan / general dental practice in Swat and Peshawar in his own surgeries. He then posted as a clinical lecturer to Khyber College of Dentistry Peshawar and trained as an Orthodontist in Lahore Pakistan 1998-2000 and completed his D. Orth. Following this he was appointed as a Senior Clinical Lecturer in Orthodontics department. He completed his fellow ship in Laser dental specialty program in 2013 from WRTH Aachan University Germany. He remained deputy Medical Superintendent of Khyber College of dentistry Peshawar for Two years assigned an additional duty. He then completed his MSc in specialized Orthodontics from international Medical College Muenster Germany2016. He remained internal examiner for under graduate Bachelor of Dental Surgery students for the last 18 years. He is now SR-Clinical lecturer in Orthodontics department Bacha khan Dental College Mardan KP Pakistan.

Abstract: Treatment timing is very important for the outcomes of all orthopedic patients for dento-skeletal imbalances in growing patients. Preceding knowledge to determine the residual growth would be helpful in forecasting treatment outcome. Functional appliance success depends on to start at appropriate time. The various maturity indices that have been used to identify stages of growth are—sexual maturation characteristics, chronological age, dental development, height, weight and skeletal development. Objective: To determine the correlation between modified middle phalanx (MP-3) and mandibular second molar mineralization stages Study Design: Cross sectional (Descriptive), Prospective study Setting: Department of Orthodontics, Khyber College of Dentistry, Peshawar Duration of Study with Dates: Six months from June 16, 2015- February 28, 2016 Materials & Methods: Panoramic radiographs of the including participants were obtained and assessment was done by Dermirjian's method for mandibular second molar calcification. Only right mandibular second molar were examined in this study. Digital radiographs of the MP-3 region was taken using the procedure described by Abdel-Kader. The left hand of each individual was placed on table with middle finger being centered on 31x 41mm X-ray film of periapical. X-ray’s cone(70 kVp and 8 mA) was oriented perpendicular to the film very close to middle finger. Exposure duration for this was 0.4 second. Results: A total of 100 patients; 58(58%) males and 42(42%) females were included. The age range was 8 to 16 years with a mean 11.56±2.34 years. The correlation between Demirjian’s stages of mandibular second molar and MP-3 stages was 0.618 which was highly statistically significant. Conclusion: There was moderate correlation(r=0.618) between mandibular second molar calcification and MP-3. Mandibular second molar calcification is helpful to determine the growth status in 37% of cases only (co-efficient of determination r2=0.375).


M-Obadah Dandashi
Fifth year student, Faculty of Dentistry, International University for Science and Technology (IUST). Damascus, Syria.
Title: Oral Rehabilitation: Case Report

Biography: Mr. M-Obadah Dandashi is a Fifth year student in the faculty of Dentistry at the International University for Science and Technology (IUST) in Damascus, Syria. He obtained the general Baccalaureate Diploma, Scientific Section, with a percentage of (93.76%) in 2013. Obadah attended the Clinical Laser Applications in Dentistry Course that is approved by WFLD. He also attended The Xviiith International scientific Conference in November, 2016. He contributed in the organization, as well as his attendance, of the First Oral Rehabilitation Congress held by the International University for Science and Technology in July, 2018. He attended the International Congress of Oral Implantologists ICOI in April, 2019. “My great pleasure is to be an update in Dentistry, and follow the latest developments and academic conferences in order to help drawing a smile on the patient’s face ” Mr. Dandashi says. For the last six months, he has been working on Oral Rehabilitation Case at his university clinics, and he is the first person to introduce the orthodontic extrusion as a practical application in the oral rehabilitation department at his university.

Abstract: An oral rehabilitation case for a female in the sixth decade of age complaining about many oral difficulties and esthetic problems. The patient was evaluated, and a comprehensive history was recorded followed by a clinical and radiographic assessment. We started by treating the periodontal condition and removing calculus, followed by oral hygiene instructions. Dental implants were used to replace missing teeth, and the right upper first premolar that was extracted immediately after internal sinus lifting. Orthodontic extrusion of the right upper canine that had cervical perforation was performed, followed by application of composite to seal the perforation with using fiber post to strengthen the root walls and building up composite as foundation for the crown. Papilloma removal was carried out via laser. After orthodontic treatment was completed, connective tissue graft was taken from the palate and was placed above the left upper incisors and canine for treating gingival recession. Apically repositioned gingival flap for the extruded canine was made in order to make its gingival margin level in harmony with adjacent teeth. E-max and zirconium crowns were used after bleaching the lower teeth (anterior and premolars). Conclusion: The importance of oral rehabilitation includes the reconstruction of functional and aesthetic aspects and draws attention to the components of the patient smile.


Mansi Thakrar
Intern at Karnavati University, Gujarat, India.
Title: Self Preservation Dentistry:Taking preventive dentistry to a new level

Biography:

Abstract: Preventive Dentistry is a concept well known in the dental field. However, the main question arising is “what if” we could create such an environment where the patients themselves are a part of our community by creating a whole new concept where the entire basis of diagnosis would be starting by the patients. It is a well known fact that the layman may not understand the importance of maintaining their oral hygiene vigilantly unless they realize any growing issue. 'Pain' is one of the most frequent chief complain of a patient which leads them to our dental chambers. But a few of those times, the pain is due to quite an advanced stage of the disease or progression of the tooth decay. Is pain the only reason why you should be visiting your dentist? I’d like to place an example of my own grandfather here. He is an 82 year old retired businessman who smokes cigarettes since he was 10 years old. Till this date he hasn’t had a single visit to the dentist. He can walk, talk and work normally without any hindrance. 1 packet per day has become his routine and he feels that it is not harmful at all because there is NO PAIN. He would not allow anyone to even check his oral cavity for any signs of a disease whatsoever. Taking preventive dentistry to a level where Self Preservation leads to a dental chamber rather than any visible symptom is the aim for generating the importance of the upcoming developments in the field of dentistry.


Mr Chuck Blakeman
Chief Relationship Officer
Title: Why Managing Your Practice Costs you Time and Money

Biography:

Abstract: It’s broken! Most of our teams are not bringing it all when they show up to work. They’re phoning it in and it’s destroying productivity, revenue, profits, and making our lives crazy! Instead of practicing dentistry, we’re managing codependent people who can’t or won’t take responsibility. It’s all on us. Let’s fix it! Dental offices of every size are changing their business practices and culture to: • Increase revenue, productivity and profits • Reduce management expenses • Attract and retain the best talent in the world (who never want to leave) Imagine your office this way: • People require no management • Team turnover is exponentially lower; a non-issue • Every single team member is 100% engaged and brings it all every day • The practice culture, beliefs and principles drive every decision at every level • People Make Meaning, not just money, and a lot more of both Get clarity on: • The management practices we inherited from the Factory System are destructive • The emerging work world will be built around The Participation Age • We must replace employees with Stakeholders, and managers with Leaders • Participation Age leadership creates faster growth, higher profits, and more longevity • How to become a Participation Age practice Is it possible THIS way of doing business would work BETTER, for both the practice and the people who work there? This isn’t a fringe idea or experimental. Many companies have worked this way for up to 50 years. We’ll profile some for you. And a growing tidal wave of companies are moving in this direction. In a few years, the Participation Age office will be commonplace. Those who embrace the Participation Age will thrive, those who don’t will be left behind. Proof: We have done this with many organizations (including those in the dental industry) and can point you to many companies of five to 10,000 Stakeholders with no managers, no employees, no written policies, no office hours (even in manufacturing facilities); where everyone is self-organized. These are the most profitable, stable and most sought after places in the world to work and are the perfect example of true “Leadership”.


Dr.Nilton Alves
Associate Professor, Universidad de La Frontera, Chile Specialist in Oral and Maxillofacial Surgery, Brazil Master in Anatomy, Universidade Federal de São Paulo, Brazil Doctor in Sciences, Universidade Federal de São Paulo, Brazil Post -Doc, Universidade de São Paulo, Brazil
Title: Intentional re-implant of left lower second molar as an alternative to extraction: a case report

Biography:

Abstract: Intentional re-implant is an alternative treatment to extraction followed by the installation of a tooth implant in situations in which normal endodontic treatment is counter-indicated or not viable. In the present study we present the case of a patient with acute apical periodontitis and important loss of supporting tissue, such that normal endodontic treatment and apical microsurgery were counter-indicated. Female patient, aged 71 years, with good oral and general health; she had good oral hygiene and was not taking any medication. The patient reported spontaneous pain which disappeared completely with the use of analgesics. In clinical examination the diagnosis was acute apical periodontitis in tooth 37. The patient reported moderate pain during mastication, and in clinical examination she presented moderate pain under vertical percussion, with slight sensitivity to horizontal percussion. The tooth had already received endodontic treatment approximately one year previously. According to the patient she had not felt any spontaneous pain for two months after that treatment, however she felt slight sensitivity to vertical percussion, exacerbated when prosthetic rehabilitation was carried out with a crown and metal retainer. Three months before the present treatment the intensity of the symptoms increased with a sensation of apex-crown pressure; the patient started taking antibiotics and analgesics. Occlusal adjustment was carried out as a point of premature contact was found after the patient reported the symptoms described. The possibilities of re-treatment by removal of the crown and the metal retainer or by endodontic microsurgery were discarded. The natural treatment alternative would be extraction with subsequent rehabilitation by implant. We opted for a more conservative treatment of extraction and immediate re-implant, after apical resection, instrumentation and retrograde obturation of the root. After the re-implant had been carried out, rigid containment was applied; this was removed after 2 weeks when the patient was gradually returning to normal mastication without applying much pressure to the region. After the containment had been removed, mobility diminished significantly, the patient presented no sensitivity to horizontal percussion and only slight sensitivity to vertical percussion. Slight inflammation was found in the free gingival margin of the vestibular region, with slight bleeding under probing. There was no alteration in the probe values before and after the procedure. The intentional re-implant treatment was successful, producing an improvement in the patient's clinical picture. X-ray examination after 1 month showed no signs of bone loss.


Julia Vysochanskaya
Sergey Morgunov Ltd “Odomtologia Somatica”, Moscow, Russian Federation
Title: Oral Cavity cytological response to dental caries injure

Biography: Julia Vysochanskaya 2011 - PhD (Dissertation "The use of bio ceramic granules with controlled kinetics of resorption to accelerate the healing of the jaw defects (experimental and clinical study)" 2008-2013 Lecturer and developer of lecture curses at the Association of Dental Hygienists in Russia 2012-2014 Lecturer and consulting doctor at 3M ESPE Russia (pediatric dentistry, periodontology, caries prevention) 2008 – nowadays practical dentist (pediatric, surgeon, orthodontist) 2012 - nowadays CEO "Odontologia Somatica" Ltd, Senior Scientist of the Immunocytological Dental Lab. Award: 2004 - Medal for labor achievements and significant contribution to the scientific research of the Ukrainian State Dentistry and Medical Academy Author of 5 patents and 5 authority rights

Abstract: Aim or Purpose: To study the oral cavity cytological response to dental caries stages. Materials and Methods: 40 patients (30 with dental caries (study group) and 10 caries free (control group)) aged between 4 and 75 years. The approach used in our study was light microscopic cytology of dental plaque (P) after night tooth brushing with standard and fluid brush and micro brush methods. The smear areas were: caries (white spot (WC), enamel (EC), dentinoenamel junction (DEJC), dentin (DC)), free caries enamel (fissures, buccal and lingual side), interdental area, gum, buccal mucosa. We analyzed 5 cytological glasses from every patient (=200), 39 morphological parameters of immune, buccal, microbiological cells and their relationship (= 7800). Results: We chose the most representative morphological parameters characterizing the stages of the carious process. Fields of vision in caries free enamel plaque characterized with single microorganisms (SM) 100%, 0-2 single standing epithelial cells (SEC) 95%, 500-700 crystals (65%) no epithelial (EP), microbial (MP), neutrophil (NP) and mononuclear cells conglomerates (MCP) (87%). WS had SM (100%), 2-5 SEC (90%), 120-170 crystals (98%). EC had 2-7 SEC (82%), 1-3 EP (65%), 2-5 NP (67%). DEJ had 5-40 NP (78%), 3-7 MP (70%), 3-8 MCP (95%). DC had 3-12 MP (67%), 2-15 NP (58%). Conclusion: Morphologically it was no significant between the dental plaque on the caries free enamel in the control and study group. Micro brush cytometry method was more indicatively then the fluid cytometry one.


Marzieh Yousefian
Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Title: Investigation on the Relationship between Gestational Diabetes, Enamel Hypoplasia and DMFT in Children

Biography: Marzieh Yousefian was born in Isfahan, Iran, in 1988. She graduated in dentistry from the Isfahan University of Medical Sciences, Iran, 2012. Her thesis was “Evaluation of Interproximal Crestal Bone Loss of Straumann Implants after the First Year of Loading in Panoramic Radiography”. Currently, she is studying Oral and Maxillofacial Medicine in Tehran University of Medical Sciences. Her thesis is “Evaluation of Expression Level of LncRNAs Contributing in the Signaling Pathways in OSCC Patients”.

Abstract: Dental caries is one of the most common chronic human disease throughout the world. Although it can be without any symptom at the initial stages, it may lead to discomfort and ultimately painful situation and make patients spend time and money to find appropriate treatment. Dental caries is elevated in dental anomalies like enamel hypoplasia. Enamel hypoplasia is caused by aberrant odontogenesis, which is initiated in the sixth week of the fetal period. Odontogenesis can be affected by systemic factors such as tissue oxygenation, metabolic disorders, and gestational diabetes. In this study, we want to determine the relationship between enamel hypoplasia and DMFT index of children and gestational diabetes of their mothers. To achieve the mentioned aim, we made a dental examination for 50 children and adolescents, between 3-12 years whose mothers had gestational diabetes and also children with healthy mothers in this regard. The results showed enamel hypoplasia and DMFT index in diabetic mothers’ children significantly higher (p=0.03). This indicates that we should schedule specific programs for the oral health care of children whose mothers had gestational diabetes.


Lucia Stanciakova
Physician - Haematologist Assistant lecturer at the National Centre of Haemostasis and Thrombosis, Department of Haematology and Transfusion Medicine
Title: Coagulation factor FXIII deficiency as the cause of prolonged bleeding after the maxillofacial surgery

Biography: Lucia Stanciakova is cureently working as Physician - Haematologist Assistant lecturer at the National Centre of Haemostasis and Thrombosis, Department of Haematology and Transfusion Medicine, Scientific Field of Expertise: Haemostasis and Thrombosis Professional Skills Upgrade: Main professional field: - inherited and acquired thrombophilia, - bleeding disorders and surgical procedures, - haemostasis in vascular disorders (preeclampsia, hypertension, diabetes mellitus), - monitoring of the antithrombotic treatment, haemostasis and tumours

Abstract: Zymogen form of coagulation factor XIII (FXIII) circulating in plasma is a pro-transglutaminase that gives a rise to cross-linked bonds of a previously synthesized fibrin clot. This way it helps in the stabilizing of the clot and preventing premature fibrinolysis. Acquired FXIII deficiency may be present due to the formation of autoantibodies or its abundant consumption. This disorder of haemostasis is clinically manifested by subcutaneous, intramuscular, intracerebral or other forms of life-threatening bleeding. Therefore, the authors would like to describe an unusual case of a patient with a rare acquired coagulation disorder under the conditions of the maxillofacial surgery. The authors present a 86-year-old man, admitted at the Department of Stomatology and Maxillofacial Surgery because of the prolonged bleeding after the extirpation of the cyst in the maxillar region. In laboratory tests, there was a finding of FXIII deficiency, mild plasminogen activator-inhibitor 1 (PAI-1) deficiency, low fibrinogen level and coagulopathy with prolonged prothrombin time. During the last month before the admission, the patient reported the development of the extensive haematoma spreading from the face to the neck and thoracic region. The treatment with fresh frozen plasma, haemostyptics and substitution of moderate posthaemorrhagic anaemia and vitamin K deficiency enabled the stabilization of this clinical condition. The treatment with above-mentioned agents was successful and the patient could be released home without the continuing bleeding. Each stomatologist and maxillofacial surgeon should take FXIII deficiency into account in the differential diagnosis of the cause of prolonged bleeding. Acknowledgement: The authors would like to thank the support of projects of the Agency for the Support of Research and Development (APVV) APVV-16-0020 and Scientific Grant Agency (Vega) 1/0168/16 and Vega 1/0549/19. Authour Biography and photograph Lucia Stanciakova, MD, PhD. received her medical degree at the Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic in 2013. Currently, after the finishing of the postgraduate study, she has been working as an assistant lecturer at the National Center of Hemostasis and Thrombosis, Department of Haematology and Transfusion Medicine at the University Hospital in Martin with the focus on haemostasis and possibilities of the monitoring of the effectiveness of the antithrombotic treatment and its modification according to the current results. She is a member of Slovak Society for Haemostasis and Thrombosis.


farida Ammouche
Associate Professor at the Faculty of Medicine of Algiers: Department of Dental Medicine.
Title: Eruptive guidance of permanent teeth and education of oro-facial functions: why and how?

Biography: Dentist Specialist in Orthodontics practicing at Mustapha University Hospital in Algiers and Associate Professor at the Faculty of Medicine of Algiers: Department of Dental Medicine.

Abstract: The eruption of the permanent teeth is done in a harmonious way when the conditions of development of the dento-alveolar arches are all united. This is not always the case, obstacles to growth as lingual or orofacial dysfunctions, parafunctions or early extractions of temporary teeth can disrupt the eruptive process in permanent dentition. Functional education using trainer treatment can stimulate the development of the arches for proper teeth placement.


Advanced Dental Research

Session Introduction

Sandrine Pouly
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Title: Design and rationale for a randomized, controlled, multicenter study in Japan to evaluate the effect of switching to the use of heat-not-burn versus continued tobacco smoking on chronic generalized periodontitis treatment outcome

Biography: Dr. Pouly is a broadly trained and experienced biologist with more than 15 years’ practice in pre-clinical and clinical research in international companies. She led several discovery projects up to clinical development, spanning from neurodegenerative to autoimmune diseases. After performing research on multiple sclerosis, both in academia and pharma companies, she moved to Philip Morris International, first to translate research findings to clinical studies, and then to manage clinical programs on smoke-free products. As a clinical scientist, she contributes to the translational strategy in dedicated therapeutic areas, including periodontitis, solving complex problems in multicultural and multidisciplinary teams.

Abstract: Quitting smoking is the most effective way to reduce the risk of smoking-related diseases that result from long-term exposure to the toxicants present in cigarette smoke. As part of tobacco harm reduction, substituting cigarettes with alternative less harmful tobacco products, such as heat-not-burn products, is a complementary approach for smokers who would otherwise continue smoking. The Tobacco Heating System (THS) is part of the heat-not burn product category. It electrically heats tobacco, instead of burning it, at much lower temperatures than cigarettes, thereby producing substantially lower levels of toxicants while being sufficiently satisfying and providing a satisfactory sensory experience and ritual. Previous clinical studies have already demonstrated a reduced exposure to toxicants as compared to cigarette smoking for smokers who switched to THS for up to three months (approaching the reductions observed in those who abstained from smoking for the duration of these studies). This study aims at further demonstrating favorable changes of switching to THS use compared with continued cigarette smoking on the response of periodontal pocket depth (PD) to mechanical periodontal therapy of patients with generalized chronic periodontitis. The evaluation criteria for the study is a mean PD reduction after therapy in all sites with initial PD ≥ 4 mm. Other clinical and pathomechanistic endpoints representative of the oral health status were also assessed, together with safety monitoring. The design is a randomized, controlled, two-arm parallel group, multicenter, six-month study, conducted in Japan, with patients having chronic generalized periodontitis who switch from cigarettes to THS or who continue to smoke cigarettes after scaling and root planning sessions (ClinicalTrials.gov: NCT03364751). Study patients had a smoking history of at least five years and did not intend to quit during the study. The basis for endpoint selection as well as duration and other considerations taken into account for the design, as well as translational aspects, will be discussed by presenting pre-clinical data.


EL Bekkay Hafid
Dentist
Title: Direct Adhesive Restorations on Anterior Teeth : Stick or stratify

Biography: I am EL Bekkay Hafid, Dentist in the private sector since 1996 I was born on October 12, 1969, I am married and have three children. I got my baccalaureate in 1987 with honors . After, I did my dental studies at the faculty of dental medicine of Rabat , Morocco, and I got my doctorate in 1995 with honorable mention, the congratulations of the juries and proposal at the price of theses. I installed my private dental office in Oujda (Morocco) in 1996 Since my installation, I have done and I do a lot of training in dentistry. I continue my postgraduate studies in implantologie and esthetic dentistry in France then in Switzerland. National and international speaker. I am fascinated by aesthetic dentistry.

Abstract: Thanks to progress in adhesive dentistry and the histological and biomimetic knowledge of dental tissues, we witness a paradigm shift in the choice of prior restoration which becomes less "Dogmatic", more rational .Indeed, biomimetics is the imitation or restoration of the biomechanics of the original tooth by the restoration. The minimal therapeutic modalities which can precede a sophisticated treatment, since the vectors of the restorative dentistry reside in the maintenance of the pulp vitality.... This is of course the purpose of restorative dentistry.The appearance and development of adhesive techniques have paved the way for continuous improvement in terms of tissue economy and aesthetics. An excellent reason allows us to dive into the mechanism of action of adhesive systems. During in this conference we will discuss how to stick fracture fragments after dental trauma. In the absence of a fragment, we will show the key points to successfully stratify composites on anterior teeth.


Luis G. Barros
Master Certified Dental Technician, Luigi Dental Inc, Tampa, FL, USA.
Title: Planning of Immediate Dentures and Over-implant Denture Prosthetics

Biography: Master Dental Technician – Luigi Dental Inc, Tampa, FL, USA. 2001– Present • Handles day to day production, training, and works in his private laboratory along with his youngest son and wife. Dental Technician– Schneider Dental Laboratory, Tampa, FL, USA 1999 – 2001 Head Dental Technician – Dental Barros “Badent”, Quito, Ecuador 1996 – 1999 • Re-launched what was formerly known as Ceramcrans Dental Laboratory to a larger state of the art facility which today is still known as Badent. • Served as technical director and handled training, complex cases, problem solving, and day to day production. Director– Larry Willman Dental Technology Institute, Quito, Ecuador 1985 – 1999 • Established the first dental technician educational institution in the country. • Worked as the director and teacher for the institution which helped produce the first generation of formally trained dental technicians in the country. Founder/Technician– Ceramcrans Dental Laboratory, Quito, Ecuador 1972 – 1996 Dental Technician – Art Dental Laboratory, Quito, Ecuador 1968 – 1972 Dental Technician – Laprodent Laboratory, Quito, Ecuador 1966 – 1968

Abstract: The correct method by which to analyze and plan for immediate dentures and over-implant dentures: (1) Consideration of the remaining dentition as having moved from the natural starting position (2) Said movements over time have modified the occlusion gradually to a new habitual occlusion (3) Acquired changes cause a displacement of the mandible towards any direction. (4) Consequently the given changes result in a displacement of the condyles to different directions. (5) Analysis of the patient’s current situation is conducted in order to determine the acquired position of the teeth and the condyles. (6) A plan for mandibular rehabilitation and premature contact elimination is performed (7) A mutually protected and balanced occlusion is reestablished and records are taken in centric relation using anterior guides or auxiliary bases. (8) According to the new information teeth are set to give a functional and aesthetic result for the patient. (9) The wax try in is utilized as a plan for implant placement in an optimal location for longevity of the prosthesis being manufacture. (10) The prosthesis is processed and finished a physiological position of the patient (centric relation) to work properly in the mouth.


Prof Andrea Escalante-Herrera
Professor
Title: Evaluation of the antimicrobial activity of tetracycline-HCl diluted in three vehicles on Fusobacterium nucleatum and Porphyromonas gingivalis

Biography:

Abstract: Background: The development and progression of periodontal diseases is the results of the dynamic interaction of microorganisms in their habitat and their alteration generates a disbiotic state. Fusobacterium nucleatum is a bridge microorganism between pioneer communities and red complex microorganisms responsible for periodontitis such as Porphyromonas gingivalis. The use of tetracycline-HCl as an adjuvant in the periodontal treatment is reported as an antiseptic but there are no clear principles of dilution or concentration. Objective: To evaluate the antimicrobial activity of tetracycline-HCl, dissolved in three vehicles: distilled water, saline solution and lidocaine 2% with epinephrine 1: 80,000 in cultures of Fusobacterium nucleatum and Porphyromonas gingivalis. Materials and Methods: The antimicrobial activity of tetracycline-HCl was evaluated in the content of 125, 250 and 500 mg dissolved in distilled water, saline and 2% lidocaine with 1: 80,000 epinephrine (Newcaina 2% New Stetic S.A.); in different times of action: 30, 60 and 120 seconds on Fusobacterium nucleatum ATCC 25586 and Porphyromonas gingivalis ATCC 33277. This is the technique of Kelsey Maurer verifying the presence or absence of colony forming units (CFU), each one by itself in triplicate with its corresponding viability controls. Results: An inhibition of Fusobacterium nucleatum and Porphyromonas gingivalis was observed by tetracycline-HCl in 125, 250 and 500 mg dissolved in distilled water, saline and 2% lidocaine with epinephrine 1: 80,000, in times of 30, 60 and 120 seconds. Conclusion: The results show that tetracycline-HCl is a good antimicrobial alternative for Fusobacterium nucleatum and Porphyromonas gingivalis regardless of the vehicle in which it was dissolved: water, saline or lidocaine 2% with epinephrine 1: 80,000, the times used here. Studies with more microorganisms and clinical studies are required to evaluate efficacy in vivo.


Marzieh Yousefian
Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Title: A Study on Serum Level of Galectin-3 and MMP-3 in Patients with Oral Squamous Cell Carcinoma

Biography: Marzieh Yousefian was born in Isfahan, Iran, in 1988. She graduated in dentistry from the Isfahan University of Medical Sciences, Iran, 2012. Her thesis was “Evaluation of Interproximal Crestal Bone Loss of Straumann Implants after the First Year of Loading in Panoramic Radiography”. Currently, she is studying Oral and Maxillofacial Medicine in Tehran University of Medical Sciences. Her thesis is “Evaluation of Expression Level of LncRNAs Contributing in the Signaling Pathways in OSCC Patients”.

Abstract: Oral SCC is the most common cancer developed in the oral region and is the sixth cancer in the human population. The mortality rate of oral cancer is reported to be 140,000 annually all around the world. Five years’ survival rate for OSCC patients is less than 50% and late diagnosis is the cause of poor prognosis of the disease. Therefore, this is critical to find accurate ways for early diagnosis such as biomarkers with adequate sensitivity and specificity. Galectin is a group of lectins, which has been determined to be effective in adhesion and cell proliferation, apoptosis, mRNA splicing and modulation of the immune system. Galectin-3 displays pathological expression in some tumors such as carcinomas of pancreas, colon, thyroid, breast, and prostate. MMP-3 is a subtype of MMP family that it’s fundamental role is to break down proteins, by which it regulates tumor cell growth, differentiation, and apoptosis. MMP-3 reveals pathological expression in many tumors; for example, melanoma, skin squamous cell carcinoma, colorectal neoplasia, gastric cancer, and breast cancer. Here, we compared the serum level of galectin-3 and MMP-3 in 45 OSCC patients with 45 healthy control subjects, by using ELISA kit. We found the levels of galectin-3 and MMP-3 in OSCC patients significantly higher in comparison with the healthy group (p<0.001). Finally, we concluded that the measurement serum level of galectin-3 and MMP-3 can be considered as a supplementary test for confirming the diagnosis of OSCC.